COMBINING STEM CELL SCIENCE AND TISSUE ENGINEERING TO STUDY THE DEVELOPMENT AND REPAIR OF HUMAN SKELETAL TISSUES”

Entity: 
Biotechnology & Biological Sciences Research Council
Type: 
European Union International Projects
Leader: 
Richard Oreffo (Universidad de Southampton, UK)
ICTP Personal: 
Departamento de Nanomateriales Poliméricos y Biomateriales. Rojo del Olmo, Luis
Start: 
13 December 2012
End: 
13 December 2012
Summary: 

We propose to harness the knowledge
surrounding normal skeletal development.
The fetal skeleton develops in two distinct
components, intramembranous (skull
and facial bones) and endochondral
(remaining skeleton) ossification.
Endochondral ossification is responsible
for the formation of bones which are the
main sites of fragility in later life. This form
of ossification depends on a pre-existing
cartilaginous model that undergoes
invasion by marrow cells and deposition
of bone onto non-resorbed cartilage struts
by marrow-derived osteoblasts. Critically
the pre cartilaginous anlages reflect the
shape, size, position and skeletal element
information in the mature skeleton. The
developmental process is tightly regulated
from early chondrogenesis through to
release of vascular growth factors once
the cartilage model is formed allowing
angiogenesis. We propose to use the
developing fetal femur to understand
the differentiation of skeletal stem cells,
skeletal development / skeletogenesis,
and the effects of key differentiation
agents and growth factors to develop our
understanding of the developing bone and
niche providing a unique regenerative
medicine paradigm. Budget: 4.000.000 £

Reference: 
BBSRC-LOLA BB/G010560/1