SUBSTITUTION OF MATERIALS OR COMPONENTS UTILISING “GREEN NANOTECHNOLOGY” (GREEN NANO-MESH)

Entity: 
UE
Type: 
European Union International Projects
Leader: 
Elvira Pujalte, Carlos (grupo ICTP)
ICTP Personal: 
Departamento de Química Macromolecular Aplicada. Gallardo Ruiz, Alberto; Reinecke, Helmut Otros participantes: Grupos de la National university of Ireland, Hebrew University of Jerusalem, Israel; Aarhus University, Denmark; Centexbel, el centro de investigación textil belga, así como las compañías Collplant, Israel; Luxilon Industries, Belgium; Proxy Biomedical Ltd., Ireland; Vornia, Ireland; Biomatech, France; and European Research Services GmbH, Germany.
Start: 
1 June 2011
End: 
31 May 2015
Summary: 

Hernia operations are among the most
common surgical procedures performed
today with over 20 million cases
annually worldwide. Hernia incidents are
associated with pain and poor quality-oflife
for the patient and lead to enormous
healthcare costs, exceeding US $48 billion
in the US annually. At present, hernia
operations rely heavily on non-degradable
polypropylene, polytetrafluoroethylene
and nylon meshes. However, these
polymers are often associated with foreign
body reaction; implant failure; and hernia
reoccurrence (over 42%). Moreover,
leaking chemicals of these polymers are
often deleterious to the surrounding cells
and tissue and immobilize post-operative
drug treatments. In addition, the process
technologies are often associated with
environmental risks. Herein, we propose
a novel approach that employs recent
advances in green nanotechnology and
sustainable raw materials for scaffold
fabrication that not only will eliminate
toxic chemicals from the processes, but
will also enhance functional repair due to
superior biological properties. Specifically, we aim to fabricate a nano-fibrous mesh
with well-defined nano-topography using
cellulose; human recombinant collagen,
derived from transgenic tobacco plants;
and biodegradable polylactic/polyglycolic
acid as raw materials. The green
credentials of this innovative approach lie
in the use of sustainable eco-friendly raw
materials that will produce biodegradable
waste products and therefore replacing
hazardous chemicals currently in use.

Budget: 147.185 euros

Reference: 
7º Programa Marco