TISSUE ENGINEERING: DESIGN AND APPLICATION OF NEW BIOACTIVE SYSTEMS.

Entidad: 
Ministerio de Educación y Ciencia.
Tipo: 
Proyecto Nacionales
Investigador Principal: 
Dr. San Román del Barrio, Julio.
Personal ICTP: 
Dr. Gallardo Ruiz, Alberto; Dra. Vázquez Lasa, Blanca; Dr. Elvira Pujalte, Carlos.
Inicio: 
1 Octubre 2007
Fin: 
30 Septiembre 2010
Resumen: 

The present project considers the following objectives: Synthesis of biodegradable polyesters with branched functionalised structures that can be used for the preparation of bioactive supports or scaffolds with activating sequences of cell adhesion and proliferation. Preparation of macro/microporous resorbable hydrogels by new techniques of cryo-polymerization, and controlled polymerization with functional gradient. Development of new “smart” polymer systems, sensitive to pH and temperature by clean CO2 supercritical technologies. New “polymer drugs” with controlled antiproliferative function for specific cells (tumoral, smooth muscle). Development of self-curing and injectable polymer formulations, of great interest to guarantee a biomechanical stabilization in bone tissue, as well as for the application of bioactive compounds (growth factors) without surgery. Controlled delivery systems of specific drugs (antibiotics, antoxidants) which could offer a fast and secure application for the stabilization of fissures of vertebras (vertebroplasties) without invasive surgery, as well as for the treatment of osteoporosis.

Referencia: 
vacio