Synthesis Group specializes in the production of polymers with special properties through synthesis or modification reactions of organic molecules. These synthetic routes include: monomer synthesis, polymerization reactions, photopolymerization and crosslinking, polymer functionalization (linear, dendrimers, and hyperbranched polymers), and surface functionalization.
The main research lines are:
1.- Development of materials with high virucidal/bactericidal activity, with a particular emphasis on textiles and polymer coatings. We have developed a strategy for surface modification that uses only water as a solvent, resulting in stable, non-toxic, environmentally friendly materials with rechargeable activity.
2.- Valorization of natural polymers from waste, to obtain materials with specific properties and high added value. This is done through functionalization or depolymerization reactions (alginate, cellulose, lignin).
3.- Synthesis of fluorescent probes (polymeric and monomeric) for the detection of biological processes and pollutants. In this field, we are involved in the COST network “Supramolecular Luminescent Chemosensors for Environmental Security” (CA22131–LUCES), where we are co-leaders of WG3 (Models, prototypes, and devices. Technology transfer and research valorization)."
Main publications
- Simona Villata, Désirée Baruffaldi, Raquel Cue Lopez, Camilla Paoletti, Paula Bosch, Lucia Napione, Andrea M. Giovannozzi, Candido Fabrizio Pirri, Enrique Martinez-Campos, Francesca Frascella, “Broadly Accessible 3D In Vitro Skin Model as a Comprehensive Platform for Antibacterial Therapy Screening”, ACS Applied Materials and Interfaces, 16(51), pp. 70284–70296, 2024
- Rubén García-Sobrino, Irene Ruiz-Blas, Carolina García, Helmut Reinecke, Carlos Elvira, Juan Rodríguez-Hernández, Enrique Martínez-Campos, Alberto Gallardo. “Hydrogels with dual sensitivity to temperature and pH in physiologically relevant ranges as supports for versatile controlled cell detachment”. Biomaterials Advances 159,213826, 2024. DOI: 10.1016/j.bioadv.2024.213826
-Rubén García-Sobrino, Carolina García, Pedro Liz-Basteiro, Helmut Reinecke, Carlos Elvira, Juan Rodríguez-Hernández, Enrique Martínez-Campos, Alberto Gallardo “Cell harvesting on robust smart thermosensitive pseudo-double networks prepared by one-step procedure”. European Polymer Journal, 209, 112925, 2024.
DOI: 10.1016/j.eurpolymj.2024.112925
- García-Sobrino, Rubén; Lago, Eugenia; Goñi, Clara; Ramos, Viviana; García, Carolina; Reinecke, Helmut; Elvira, Carlos; Rodríguez-Hernández, Juan; Gallardo, Alberto; Martínez-Campos, Enrique. “Fabrication of 3D cylindrical thermosensitive hydrogels as supports for cell culture and detachment of tubular cell sheets”. Biomaterials Advances 144, 213210, 2023.
DOI: 10.1016/j.bioadv.2022.213210
- Michael Zanon, Raquel Cue-López, Enrique Martínez-Campos, Paula Bosch, Davy-Louis Versace, Hassan Hayek, Nadia Garino, Candido Fabrizio Pirri, Marco Sangermano, Annalisa Chiappone, “Bioderived dyes mediated DLP 3D-printing of chitosan hydrogels for tissue engineering”, Additive Manufacturing 69 (2023) 103553.
- Gustavo González, María Arévalo, Annalisa Chiappone, Enrique Martínez, Candido Fabrizio Pirri, Ignazio Roppolo, Paula Bosch, “A facile and green microwave-assisted strategy to induce surface properties on complex-shape polymeric 3D printed structures”, Macromol. Mater. Eng. 2023, 2300118.
- C. Salgado, R. Cue, V. Yuste, L. Montalvillo-Jiménez, P. Prendes, S. Paz, A. Vázquez, A. Alcamí, C. García, E. Martínez-Campos, P. Bosch, "Clear polyurethane coatings with excellent reactivable Virucidal properties: preparation, characterization and rapid Inactivation of human coronaviruses 229E and SARS-CoV-2”, Appl. Mater. Today 32 (2023) 101828.
- Michael Zanon, Laura Montalvillo-Jiménez, Paula Bosch, Raquel Cue-López, Enrique Martínez-Campos, Marco Sangermano, Annalisa Chiappone, “Photocurable Thiol–yne Alginate Hydrogels for Regenerative Medicine Purposes”, Polymers, 2022, 14, 4709.
- P. Bosch, D. Staneva, E. Vasileva-Tonkova, P. Grozdanov, I. Nikolova, R. Kukeva, R. Stoyanova, I. Grabchev, “Hyperbranched Polymers Modified with Dansyl Units and Their Cu(II) Complexes. Bioactivity Studies”, Materials 2020, 13, 4574.
Main projects
- “Funcionalización de Polivinil-Lactamas hidrosolubles con Interés biomédico para su aplicación en procesos de recubrimientos e impresión 3D de hidrogeles” PID2023-151687OB-100. Duración: 09/2024-12/2027. Financiación: 187.500€
- “Polymerización de r-MMA reciclado. Estrategias sostenibles y verdes” (Ministerio de Ciencia e Innovación, Proyectos de Transición Ecológica y Transición Digital 2021)
- “Preparación de superficies poliméricas con actividad viricida recargable. Aplicaciones como recubrimientos, textiles y sistemas de inactivación de virus en aire” (SGL2103036, UE–NextGenerationEU), DURACIÓN: 06/2021-12/2022, IP: Paula Bosch, Financiación: 180.000€.
- “Textiles y recubrimientos poliméricos funcionales recargables con previsible actividad anti-SARS-CoV-2” (CSIC,COVID 19-119), DURACIÓN: 11/05/2020-10/05/2021, IP: P. Bosch. Financiación: 120.000€.
- “Textile materials to prevent the spread of SARS-CoV2 and other pathogens”, (Bulgarian Academy of Science, REF: por asignar), IP: Petar Todorov Todorov, IP-ICTP: Paula Bosch, DURACIÓN: Aprobado sep 2020, FINANCIACIÓN: 120 000 BGN (60 000€).
- “Smart textile materials with ecological and biomedical applications”, (Bulgarian Academy of Science, КП-06-Н37/27 2019), IP: Desislava Staneva Grabcheva, IP-ICTP: Paula Bosch, DURACIÓN: 01/01/2019-31/12/2019, FINANCIACIÓN: 120 000 BGN (60 000€).
- “Nuevas Tecnologías de Fabricación y Optimización de Tejidos: La Piel como Sistema Modelo” (Comunidad de Madrid, P2018/BAA-4480), DURACIÓN: 2019-2021, Coordinador: Pablo Acedo, IP-ICTP: Carlos Elvira. Financiación: 840.000€.
- “Plataformas poliméricas termosensibles para manipulación celular” (RTI2018-096328-B-I00, Ministerio de Ciencia, Innovación y Universidades), DURACIÓN: 2019-2021, IPs: A. Gallardo y C. Elvira. FINANCIACIÓN: 140.000€.