The activity of Biomaterials Group (www.biomateriales.ictp.csic.es) is mainly focused on two clearly differentiated lines of research: the development of controlled release systems for bioactive molecules and the development of scaffolds for tissue engineering. Both lines continually converge, giving rise to high-performance biomaterials and medical devices.
The Group is specialized in:
- Synthesis and preparation of monomers with pharmacological activity (antithrombogenic, anti-inflammatory, antitumor, antioxidant, antiangiogenic, etc.)
- Synthesis and preparation of bioactive polymers with specific therapeutic action
- Synthesis of nanostructured polymers for the preparation of self-assembled systems
- Modification of natural polymers for the development of hydrogels
- Development of composite materials for application in biomedicine
- Study of the biological effects of biomaterials on eukaryotic and prokaryotic cells. Cytotoxicity and biocompatibility determination, inflammation studies, anticancer effect studies, apoptosis. Antimicrobial activity using gram+ and gram- bacteria.
- In vivo animal tests in collaboration with other institutions (University of Salamanca, University of Alcalá de Henares, Puerta de Getafe Hospital, Ramón y Cajal Hospital, ISCIII…)
All of this translates into relevant contributions to the development of new nanoparticles for the transport and release of bioactive molecules (e.g. drugs, vitamins, iRNA, growth factors, etc.), 3D printing hydrogels and bioinks for tissue engineering, coatings for biomedical devices, etc.
Main publications
AUTORES/AS (p.o. de firma): Miguel Huerta-Madroñal, Eva Espinosa-Cano, María Rosa Aguilar, Blanca Vázquez-Lasa
TÍTULO: Antiaging properties of antioxidant photoprotective polymeric nanoparticles loaded with coenzyme-Q10
REF. REVISTA/LIBRO: BIOMATERIALS ADVANCES, 145, 213247
FECHA PUBLICACIÓN: 2023
CLAVE: A
ÍNDICE DE IMPACTO: 8.457 (Q1)
AUTORES/AS (p.o. de firma): Miryam Criado-González, Eva Espinosa-Cano, Luis Rojo, Fouzia Boulmedais, Maria Rosa Aguilar, Rebeca Hernández
TÍTULO: Injectable Tri-peptide/Polymer Nanoparticles Supramolecular Hydrogel: a Candidate for Treatment of Inflammatory Pathologies
REF. REVISTA/LIBRO: ACS Applied Materials and Interfaces, 2022, 14, 8, 10068–10080
FECHA PUBLICACIÓN: 2022
CLAVE: A
ÍNDICE DE IMPACTO: 8.75 (Q1)
AUTORES/AS (p.o. de firma): Roberto Vázquez, Francisco J. Caro-León, Alberto Nakal, Susana Ruiz, Carmen Donoro, Luis García-Fernández, Blanca Vázquez-Lasa, Julio San Román, Jesús Sanz, Pedro García, María Rosa Aguilar
TÍTULO: DEAE-chitosan nanoparticles as a pneumococcus-biomimetic material for the development of antipneumococcal therapeutics
REF. REVISTA/LIBRO: CARBOHYDRATE POLYMERS, 273, 118605
FECHA PUBLICACIÓN: 2021
CLAVE: A
ÍNDICE DE IMPACTO: 7.182 (Q1)
AUTORES/AS (p.o. de firma): Eva Espinosa-Cano, Miguel Huerta-Madroñal, Patricia Cámara-Sánchez, Joaquin Seras-Franzoso, Simó Schwartz Jr., Ibane Abasolo*, Julio. San Román, María Rosa Aguilar
TÍTULO: HA-coated naproxen-nanoparticles selectively target breast cancer stem cells through COX-independent pathways
REF. REVISTA/LIBRO: MATERIALS SCIENCE & ENGINEERING C, 124, 112024
FECHA PUBLICACIÓN: 2021
CLAVE: A
ÍNDICE DE IMPACTO: 5.88 (Q1)
AUTORES/AS (p.o. de firma): Gloria María Pontes-Quero, Lorena Benito-Garzón, Juan Pérez Cano, María Rosa Aguilar, Blanca Vázquez-Lasa
TÍTULO: Amphiphilic polymeric nanoparticles encapsulating curcumin: antioxidant, anti-inflammatory and biocompatibility studies
REF. REVISTA/LIBRO: MATERIALS SCIENCE & ENGINEERING C, 121, 111793
FECHA PUBLICACIÓN: 2021
CLAVE: A
ÍNDICE DE IMPACTO: 5.88 (Q1)
Main projects
- Building knowledge and tools for the sustainable microbial fighting through sensing and responsive polysaccharide-based materials, NET4MAT. (Horizon Europe Framework Programme (HORIZON), Marie-Curie STAFF EXCHANGE, Ref. HORIZON-MSCA-2022-SE-01; 31/12/2027)
- Nuevas soluciones terapéuticas para el tratamiento de la piel radiada, RADIOPROTECT. (Comunidad de Madrid, CAM, Ref. P2022/BMD-7406, 31/12/2026)
- Investigación industrial para la obtención de nuevas fuentes proteicas alternativas, sostenibles, nutritivas y trazables a través de bioprocesos mediante uso de IA. (Centro para el Desarrollo Tecnológico Industrial CDTI, PROYECTO MISIONES, Ref. MIG-20221025, 31/12/2025)
- Desarrollos basados en polifenoles para retos clínicos en medicina regenerativa pendientes de resolver, POLYPHILLED. (Ministerio de Ciencia e Innovación, Ref. PID2020-114086RB-I00; 31/08/2024)
- Contrato de I+D con la empresa LVD Biotech para el desarrollo de dispositivos médicos