Innovative pharmapolymers and nanoparticles for applications in nanomedicine

Polymers feature a great potential for the delivery of various active pharmaceutical ingredients. An optimum carrier material should be non-toxic, bind and protect its cargo from degradation, be invisible to the immune system and direct cargo to its desired place of action. Although promising polymers exist to fulfill one or two of the requirements, only few are currently exploited for these purposes. With focus on inflammation-related diseases, the lecture provides an overview about how traditional polymers can be modified, coupled to relevant building blocks, or be replaced by more tailor-made alternatives. In particular the solution self-assembly behavior of the (block co) polymers has to be studied in detail (e.g. by analytical ultracentrifugation, AF4, (cryo)TEM or others).

 

Selected references: Angew. Chem. Int. Ed. 2018, 57, 2479; Biomacromolecules 2018, 19, 748; Biomacromolecules 2017, 18, 3280; Polym. Chem. 2017, 8, 6086; Polym. Chem. 2017, 8, 1328; Anal. Chem. 2017, 89, 1185.

 

 Ulrich Sigmar Schubert (born 17 July 1969, Tübingen) is a professor of Chemistry at University of Jena. He studied chemistry at the Universities of Frankfurt and Bayreuth (both Germany) and the Virginia Commonwealth University, Richmond, Virginia, United States. His Ph.D. work was performed under the supervision of Professor Eisenbach (Bayreuth, Germany) and George R. Newkome, Florida, United States. In 1995, he obtained his doctorate with Eisenbach. After a postdoctoral training with Jean-Marie Lehn (Nobel Laureate in 1987) at the University of Strasbourg (France), he moved to the Technical University of Munich (Germany) to obtain his habilitation in 1999. From 1999 to spring 2000 he held a temporal position as a professor at the Center for NanoScience at the Technical University of Munich. He became a Full-Professor in summer 2000 at the Eindhoven University of Technology. Since summer 2007, Schubert teaches at the University of Jena and holds the chair for Organic and Macromolecular Chemistry. From 2010, he is the scientific chairman in the fields of HTE at the Dutch Polymer Institute. In addition, he acts as the Director of the "Institute of Organic and Macromolecular Chemistry" and directs the research cluster "Innovative Materials and Technologies" at the University of Jena. He currently is the director of the Jena Center for Soft Mater (JCSM) and the Center for Energy and Environmental Chemistry Jena (CEEC Jena).